About this Medicine article

Defining the clinical course of multiple sclerosis: The 2013 revisions by F. D. Lublin; S. C. Reingold; J. A. Cohen; G. R. Cutter; P. S. Sorensen; A. J. Thompson; J. S. Wolinsky; L. J. Balcer; B. Banwell; F. Barkhof; B. Bebo; P. A. Calabresi; M. Clanet; G. Comi; R. J. Fox; M. S. Freedman; A. D. Goodman; M. Inglese; L. Kappos; B. C. Kieseier; J. A. Lincoln; C. Lubetzki; A. E. Miller; X. Montalban; P. W. O'Connor; J. Petkau; C. Pozzilli; R. A. Rudick; M. P. Sormani; O. Stuve; E. Waubant; C. H. Polman is a Medicine article available to read on EtoBox.

Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. Increased understanding of MS and its pathology, coupled with general concern that the original descriptors may not adequately reflect more recently identified clinical aspects of the disease, prompted a re-examination of MS disease phenotypes by the International Advisory Committee on Clinical Trials of MS. While imaging and biological markers that might provide objective criteria for separating clinical phenotypes are lacking, we propose refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression. Strategies for future research to better define phenotypes are also outlined.

Author

F. D. Lublin; S. C. Reingold; J. A. Cohen; G. R. Cutter; P. S. Sorensen; A. J. Thompson; J. S. Wolinsky; L. J. Balcer; B. Banwell; F. Barkhof; B. Bebo; P. A. Calabresi; M. Clanet; G. Comi; R. J. Fox; M. S. Freedman; A. D. Goodman; M. Inglese; L. Kappos; B. C. Kieseier; J. A. Lincoln; C. Lubetzki; A. E. Miller; X. Montalban; P. W. O'Connor; J. Petkau; C. Pozzilli; R. A. Rudick; M. P. Sormani; O. Stuve; E. Waubant; C. H. Polman

Publisher

Lippincott Williams and Wilkins; Ovid Technologies (Wolters Kluwer) - American Academy of Neurology; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 0028-3878)

Published

2014

Language

EN

Field

Medicine (Health Sciences)