About this Medicine article

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop by I.G. McKeith; D. Galasko; K. Kosaka; E.K. Perry; D.W. Dickson; L.A. Hansen; D.P. Salmon; J. Lowe; S.S. Mirra; E.J. Byrne; G. Lennox; N.P. Quinn; J.A. Edwardson; P.G. Ince; C. Bergeron; A. Burns; B.L. Miller; S. Lovestone; D. Collerton; E.N.H. Jansen; C. Ballard; R.A.I. de Vos; G.K. Wilcock; K.A. Jellinger; R.H. Perry is a Medicine article available to read on EtoBox.

Recent neuropathologic autopsy studies found that 15 to 25% of elderly demented patients have Lewy bodies (LB) in their brainstem and cortex, and in hospital series this may constitute the most common pathologic subgroup after pure Alzheimer's disease (AD).The Consortium on Dementia with Lewy bodies met to establish consensus guidelines for the clinical diagnosis of dementia with Lewy bodies (DLB) and to establish a common framework for the assessment and characterization of pathologic lesions at autopsy. The importance of accurate antemortem diagnosis of DLB includes a characteristic and often rapidly progressive clinical syndrome, a need for particular caution with neuroleptic medication, and the possibility that DLB patients may be particularly responsive to cholinesterase inhibitors. We identified progressive disabling mental impairment progressing to dementia as the central feature of DLB. Attentional impairments and disproportionate problem solving and visuospatial difficulties are often early and prominent. Fluctuation in cognitive function, persistent well-formed visual hallucinations, and spontaneous motor features of parkinsonism are core features with diagnostic signific

Author

I.G. McKeith; D. Galasko; K. Kosaka; E.K. Perry; D.W. Dickson; L.A. Hansen; D.P. Salmon; J. Lowe; S.S. Mirra; E.J. Byrne; G. Lennox; N.P. Quinn; J.A. Edwardson; P.G. Ince; C. Bergeron; A. Burns; B.L. Miller; S. Lovestone; D. Collerton; E.N.H. Jansen; C. Ballard; R.A.I. de Vos; G.K. Wilcock; K.A. Jellinger; R.H. Perry

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

1996

Language

EN

Field

Medicine (Health Sciences)