About this Medicine article

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline by Julie R. Brahmer; Christina Lacchetti; Bryan J. Schneider; Michael B. Atkins; Kelly J. Brassil; Jeffrey M. Caterino; Ian Chau; Marc S. Ernstoff; Jennifer M. Gardner; Pamela Ginex; Sigrun Hallmeyer; Jennifer Holter Chakrabarty; Natasha B. Leighl; Jennifer S. Mammen; David F. McDermott; Aung Naing; Loretta J. Nastoupil; Tanyanika Phillips; Laura D. Porter; Igor Puzanov; Cristina A. Reichner; Bianca D. Santomasso; Carole Seigel; Alexander Spira; Maria E. Suarez-Almazor; Yinghong Wang; Jeffrey S. Weber; Jedd D. Wolchok; John A. Thompson is a Medicine article available to read on EtoBox.

Purpose To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events in patients treated with immune checkpoint inhibitor (ICPi) therapy. Methods A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology, neurology, hematology, emergency medicine, nursing, trialist, and advocacy was convened to develop the clinical practice guideline. Guideline development involved a systematic review of the literature and an informal consensus process. The systematic review focused on guidelines, systematic reviews and meta-analyses, randomized controlled trials, and case series published from 2000 through 2017. Results The systematic review identified 204 eligible publications. Much of the evidence consisted of systematic reviews of observational data, consensus guidelines, case series, and case reports. Due to the paucity of high-quality evidence on management of immune-related adverse events, recommendations are based on expert consensus. Recommendations Recommendations for specific organ system–based toxicity diagnosis and manage

Author

Julie R. Brahmer; Christina Lacchetti; Bryan J. Schneider; Michael B. Atkins; Kelly J. Brassil; Jeffrey M. Caterino; Ian Chau; Marc S. Ernstoff; Jennifer M. Gardner; Pamela Ginex; Sigrun Hallmeyer; Jennifer Holter Chakrabarty; Natasha B. Leighl; Jennifer S. Mammen; David F. McDermott; Aung Naing; Loretta J. Nastoupil; Tanyanika Phillips; Laura D. Porter; Igor Puzanov; Cristina A. Reichner; Bianca D. Santomasso; Carole Seigel; Alexander Spira; Maria E. Suarez-Almazor; Yinghong Wang; Jeffrey S. Weber; Jedd D. Wolchok; John A. Thompson

Published

2018

Language

EN

Field

Medicine (Health Sciences)