About this Biochemistry, Genetics and Molecular Biology article
The Immune Contexture in Human Tumours: Impact on Clinical Outcome by Wolf Herman Fridman; Franck Pagès; Catherine Sautès-Fridman; Jérôme Galon is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients. Glossary Cytotoxic T cells CD3 + CD8 + effector T cells with cytotoxic granules that contain perforin and granzymes, which are released on interaction with target cells expressing cognate antigen. This leads to the death of target cells by apoptosis. Dendritic cells Cells that capture microorganisms or dead tumour cells and that process them to present antigen to T cells in secondary or tertiary lymphoid organs. They express high levels of co-stimulatory molecules, which allows them to activate naive T cells. High endothelial venules Specialized venules that occur in secondary lymphoid organs, except the spleen. They allow continuous transmigration of lymphocytes as a consequence of the constitutive expression of adhesion molecules and chemokines at their luminal surface.
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Wolf Herman Fridman; Franck Pagès; Catherine Sautès-Fridman; Jérôme Galon
- Publisher
- Springer Science and Business Media LLC
- Published
- 2012
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)