About this Medicine article
American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer by Antonio C. Wolff; M. Elizabeth H. Hammond; Jared N. Schwartz; Karen L. Hagerty; D. Craig Allred; Richard J. Cote; Mitchell Dowsett; Patrick L. Fitzgibbons; Wedad M. Hanna; Amy Langer; Lisa M. McShane; Soonmyung Paik; Mark D. Pegram; Edith A. Perez; Michael F. Press; Anthony Rhodes; Catharine Sturgeon; Sheila E. Taube; Raymond Tubbs; Gail H. Vance; Marc van de Vijver; Thomas M. Wheeler; Daniel F. Hayes is a Medicine article available to read on EtoBox.
## Purpose To develop a guideline to improve the accuracy of human epidermal growth factor receptor 2 (HER2) testing in invasive breast cancer and its utility as a predictive marker. ## Methods The American Society of Clinical Oncology and the College of American Pathologists convened an expert panel, which conducted a systematic review of the literature and developed recommendations for optimal HER2 testing performance. The guideline was reviewed by selected experts and approved by the board of directors for both organizations. ## Results Approximately 20% of current HER2 testing may be inaccurate. When carefully validated testing is performed, available data do not clearly demonstrate the superiority of either immunohistochemistry (IHC) or in situ hybridization (ISH) as a predictor of benefit from anti-HER2 therapy. ## Recommendations The panel recommends that HER2 status should be determined for all invasive breast cancer. A testing algorithm that relies on accurate, reproducible assay performance, including newly available types of brightfield ISH, is proposed. Elements to reliably reduce assay variation (for example, specimen handling, assay exclusion, and reporting criteria)
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- Author
- Antonio C. Wolff; M. Elizabeth H. Hammond; Jared N. Schwartz; Karen L. Hagerty; D. Craig Allred; Richard J. Cote; Mitchell Dowsett; Patrick L. Fitzgibbons; Wedad M. Hanna; Amy Langer; Lisa M. McShane; Soonmyung Paik; Mark D. Pegram; Edith A. Perez; Michael F. Press; Anthony Rhodes; Catharine Sturgeon; Sheila E. Taube; Raymond Tubbs; Gail H. Vance; Marc van de Vijver; Thomas M. Wheeler; Daniel F. Hayes
- Publisher
- American Society of Clinical Oncology (ASCO)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)