About this Medicine article
EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma by European Association for the Study of the Liver; European Organisation for Research and Treatment of Cancer is a Medicine article available to read on EtoBox.
els-evidence-adult-treatment/HealthProfessional. Accessed . ⁄ The randomized, double-blinded controlled clinical trial (1i) is the gold standard of study design. Meta-analyses of randomized studies are placed in the same category of strength of evidence as are randomized studies. ⁄⁄ This category includes trials in which treatment allocation was made by birth date, chart number (so-called quasi randomized studies) or subset analyses of randomized studies (or randomized phase II studies). ⁄⁄⁄ All other prospective (cohort studies) or retrospective studies (case-control studies, case series). # These end-points may be subjected to investigator interpretation. More importantly, they may, but do not automatically, translate into direct patient benefit such as survival or quality of life. Nevertheless, it is rational in many circumstances to use a treatment that improves these surrogate end-points while awaiting a more definitive end-point to support its use.
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- European Association for the Study of the Liver; European Organisation for Research and Treatment of Cancer
- Publisher
- Elsevier BV
- Published
- 2012
- Language
- EN
- Field
- Medicine (Health Sciences)