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Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines by Scott M. Grundy; James I. Cleeman; C. Noel Bairey Merz; H. Bryan Brewer; Luther T. Clark; Donald B. Hunninghake; Richard C. Pasternak; Sidney C. Smith; Neil J. Stone is a Medicine article available to read on EtoBox.

The Adult Treatment Panel III (ATP III) of the National Cholesterol Education Program issued an evidence-based set of guidelines on cholesterol management in 2001. Since the publication of ATP III, 5 major clinical trials of statin therapy with clinical end points have been published. These trials addressed issues that were not examined in previous clinical trials of cholesterol-lowering therapy. The present document reviews the results of these recent trials and assesses their implications for cholesterol management. Therapeutic lifestyle changes (TLC) remain an essential modality in clinical management. The trials confirm the benefit of cholesterol-lowering therapy in high-risk patients and support the ATP III treatment goal of low-density lipoprotein cholesterol (LDL-C) <100 mg/dL. They support the inclusion of patients with diabetes in the high-risk category and confirm the benefits of LDL-lowering therapy in these patients. They further confirm that older persons benefit from therapeutic lowering of LDL-C. The major recommendations for modifications to footnote the ATP III treatment algorithm are the following. In high-risk persons, the recommended LDL-C goal is <100 mg/dL, bu

Author

Scott M. Grundy; James I. Cleeman; C. Noel Bairey Merz; H. Bryan Brewer; Luther T. Clark; Donald B. Hunninghake; Richard C. Pasternak; Sidney C. Smith; Neil J. Stone

Publisher

Lippincott Williams and Wilkins; Ovid Technologies Wolters Kluwer -American Heart Association; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 0009-7322)

Published

2004

Language

EN

Field

Medicine (Health Sciences)