About this Medicine article
Molecular epidemiology of Escherichia coli causing bloodstream infections in a centralized Canadian region: a population-based surveillance study by Holland, M.S.; Nobrega, D.; Peirano, G.; Naugler, C.; Church, D.L.; Pitout, J.D.D. is a Medicine article available to read on EtoBox.
## Objectives: Escherichia coli is a leading cause of bloodstream infections worldwide, and is responsible for substantial patient morbidity, mortality and healthcare expenditure. understanding the molecular epidemiology of e. coli will aid in designing superior treatment and prevention strategies. ## Methods: We undertook a population-based surveillance study describing the clinical factors, susceptibility patterns, incidence rates and geographical distribution of sequence types (sts) among e. coli isolates (n = 686) causing incident bloodstream infections in a centralized canadian region during 2016. sts were identified using a seven-single-nucleotide-polymorphism quantitative pcr (n = 422) and sequencing of certain house-keeping genes (n = 249). ## Results: The annual population incidence rate of e. coli bloodstream infections was 48.8/100 000 patient years, and five dominant clones (st131, st73, st69, st95 and st1193) accounting for 55% (378/686) of the population were identified, each with a specific geographical distribution within calgary. st131 was the most common (overall incidence rate of 10.4/100 000 patient years), an antimicrobial-resistant (amr) clone affecting mainly
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- Author
- Holland, M.S.; Nobrega, D.; Peirano, G.; Naugler, C.; Church, D.L.; Pitout, J.D.D.
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Limited; Elsevier BV; Test accounts (ISSN 1198-743X)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)