About this Medicine article

Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS-SPSP International Workshop* by I. Litvan; Y. Agid; D. Calne; G. Campbell; B. Dubois; R. C. Duvoisin; C. G. Goetz; L. I. Golbe; J. Grafman; J. H. Growdon; M. Hallett; J. Jankovic; N. P. Quinn; E. Tolosa; D. S. Zee is a Medicine article available to read on EtoBox.

To improve the specificity and sensitivity of the clinical diagnosis of progressive supranuclear palsy (PSP, Steele-Richardson-Olszewski syndrome), the National Institute of Neurological Disorders and Stroke (NINDS) and the Society for PSP, Inc. (SPSP) sponsored an international workshop to develop an accurate and universally accepted set of criteria for this disorder. The NINDS-SPSP criteria, which were formulated from an extensive review of the literature, comparison with other previously published sets of criteria, and the consensus of experts, were validated on a clinical data set from autopsy-confirmed cases of PSP. The criteria specify three degrees of diagnostic certainty: possible PSP, probable PSP, and definite PSP. Possible PSP requires the presence of a gradually progressive disorder with onset at age 40 or later, either vertical supranuclear gaze palsy or both slowing of vertical saccades and prominent postural instability with falls in the first year of onset, as well as no evidence of other diseases that could explain these features. Probable PSP requires vertical supranuclear gaze palsy, prominent postural instability, and falls in the first year of onset, as well as

Author

I. Litvan; Y. Agid; D. Calne; G. Campbell; B. Dubois; R. C. Duvoisin; C. G. Goetz; L. I. Golbe; J. Grafman; J. H. Growdon; M. Hallett; J. Jankovic; N. P. Quinn; E. Tolosa; D. S. Zee

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

1996

Language

EN

Field

Medicine (Health Sciences)