About this Medicine article
Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease by Randall J. Bateman; Chengjie Xiong; Tammie L.S. Benzinger; Anne M. Fagan; Alison Goate; Nick C. Fox; Daniel S. Marcus; Nigel J. Cairns; Xianyun Xie; Tyler M. Blazey; David M. Holtzman; Anna Santacruz; Virginia Buckles; Angela Oliver; Krista Moulder; Paul S. Aisen; Bernardino Ghetti; William E. Klunk; Eric McDade; Ralph N. Martins; Colin L. Masters; Richard Mayeux; John M. Ringman; Martin N. Rossor; Peter R. Schofield; Reisa A. Sperling; Stephen Salloway; John C. Morris is a Medicine article available to read on EtoBox.
## Background: The order and magnitude of pathologic processes in alzheimer's disease are not well understood, partly because the disease develops over many years. autosomal dominant alzheimer's disease has a predictable age at onset and provides an opportunity to determine the sequence and magnitude of pathologic changes that culminate in symptomatic disease. ## Methods: In this prospective, longitudinal study, we analyzed data from 128 participants who underwent baseline clinical and cognitive assessments, brain imaging, and cerebrospinal fluid (csf) and blood tests. we used the participant's age at baseline assessment and the parent's age at the onset of symptoms of alzheimer's disease to calculate the estimated years from expected symptom onset (age of the participant minus parent's age at symptom onset). we conducted cross-sectional analyses of baseline data in relation to estimated years from expected symptom onset in order to determine the relative order and magnitude of pathophysiological changes. ## Results: Concentrations of amyloid-beta (aβ)(42) in the csf appeared to decline 25 years before expected symptom onset. aβ deposition, as measured by positron-emission tomograp
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- Author
- Randall J. Bateman; Chengjie Xiong; Tammie L.S. Benzinger; Anne M. Fagan; Alison Goate; Nick C. Fox; Daniel S. Marcus; Nigel J. Cairns; Xianyun Xie; Tyler M. Blazey; David M. Holtzman; Anna Santacruz; Virginia Buckles; Angela Oliver; Krista Moulder; Paul S. Aisen; Bernardino Ghetti; William E. Klunk; Eric McDade; Ralph N. Martins; Colin L. Masters; Richard Mayeux; John M. Ringman; Martin N. Rossor; Peter R. Schofield; Reisa A. Sperling; Stephen Salloway; John C. Morris
- Publisher
- Massachusetts Medical Society
- Published
- 2012
- Language
- EN
- Field
- Medicine (Health Sciences)